Quantification of Brain Glucose Metabolism by 18F-FDG PET with Real-Time Arterial and Image-Derived Input Function in Mice
نویسندگان
چکیده
منابع مشابه
Quantification of brain glucose metabolism by 18F-FDG PET with real-time arterial and image-derived input function in mice.
UNLABELLED Kinetic modeling of PET data derived from mouse models remains hampered by the technical inaccessibility of an accurate input function (IF). In this work, we tested the feasibility of IF measurement with an arteriovenous shunt and a coincidence counter in mice and compared the method with an image-derived IF (IDIF) obtained by ensemble-learning independent component analysis of the h...
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Dynamic FDG-PET imaging was used to study inflammation in lungs of mice following administration of a virulent strain of Klebsiella (K.) pneumoniae. Net whole-lung FDG influx constant (K(i)) was determined in a compartment model using an image-derived blood input function. Methods. K. pneumoniae (~3 x 10(5) CFU) was intratracheally administered to six mice with 6 other mice serving as controls....
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UNLABELLED Measurement of arterial input function is a restrictive aspect for quantitative (18)F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS In the present study, we took advantage of the high spatial resolution of a recent dedicated small-animal scanner to extract the input function from the (18)F-FDG PET ima...
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Measurement of arterial input function (AIF) for quantitative positron emission tomography (PET) studies is technically challenging. The present study aimed to develop a method based on a standard arterial input function (SIF) to estimate input function without blood sampling. We performed (18)F-fluolodeoxyglucose studies accompanied by continuous blood sampling for measurement of AIF in 11 rat...
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PURPOSE We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (K(m)) from dynamic [(18)F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance K(m) values without blood sampling. MATERIALS AND METHODS We evaluated eig...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2012
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.112.107474